The Exon 3-Deleted/Full-Length Growth Hormone Receptor Polymorphism Did Not Influence Growth Response to Growth Hormone Therapy over Two Years in Prepubertal Short Children Born at Term with Adequate Weight and Length for Gestational Age
نویسندگان
چکیده
منابع مشابه
Growth of short children born small for gestational age and their response to growth hormone therapy.
Growth hormone [GH] is licensed for use in children born small for gestational age (SGA) who fail to catch-up. We retrospectively compared the response of twenty children born SGA (who satisfied the auxological criteria) to growth hormone (Group I) versus randomly selected age and sex matched controls from a group of SGA children with growth related complaints, not treated with GH (Group II). A...
متن کاملInfluence of growth hormone receptor exon 3 polymorphism on growth response in children with growth hormone deficiency
Results The distribution of GHR exon 3 isoforms in children with GHD demonstrated that the frequency of fl/fl (82.8%) is higher than that in most of European studies. There was no significant difference in baseline height SDS between 2 groups. Height velocity during the first year of growth hormone replacement therapy tended to be higher in subjects who have d3 allele (fl/d3 and d3/d3), but the...
متن کاملexon 3-deleted and full-length growth hormone receptor polymorphism frequencies in an iranian population
the functional role of the exon 3 growth hormone receptor ( d3 ghr) polymorphism in human and its distributions in different populations is not clearly understood. the presence of full length growth hormone ( fl ghr) is the most important in metabolic risk factors. the aim of this study was to define the frequency distribution of d3 ghr/full-length ghr in an iranian population. the presence of...
متن کاملMethylphenidate and the Response to Growth Hormone Treatment in Short Children Born Small for Gestational Age
BACKGROUND Growth hormone (GH) treatment has become a frequently applied growth promoting therapy in short children born small for gestational age (SGA). Children born SGA have a higher risk of developing attention deficit hyperactivity disorder (ADHD). Treatment of ADHD with methylphenidate (MP) has greatly increased in recent years, therefore more children are being treated with GH and MP sim...
متن کاملThe Distribution of Exon 3-Deleted/Full-Length Growth Hormone Receptor Polymorphism in the Turkish Population
OBJECTIVE The exon 3-deleted/full-length (d3/fl) growth hormone receptor (d3/fl-GHR) polymorphism has been associated with responsiveness to GH therapy in some children and also with adult height variation in the general population. We aimed to evaluate the distribution of d3/fl-GHR polymorphism in a Turkish population. METHODS The study included 477 (54 females/423 males) healthy adults with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2008
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2007-2180